Frequency of ABO Incompatibility in Neonates Presenting with Unconjugated Hyperbilirubinemia

Abstract

Objective: To find the frequency of ABO incompatibility in newborns presenting with neonatal jaundice.

Study Design: Cross sectional study

Place and Duration of Study: This study was conducted at the Medicine Unit II, Pediatric Department, Mayo Hospital, Lahore from November, 2017 to May, 2018.

Materials and Methods: 100 neonates who fulfill the inclusion criteria were included in the study. Then blood sample was obtained by using pricker from foot and three drops will be obtained. Antigens A & B was applied and blood group of neonate was noted. Blood group of mother was also assessed. If blood group of neonate was A, B or AB and blood group of mother was O, then ABO incompatibility was labeled. All data was entered in specially designed Performa. The data was analyzed through SPSS version 21.

Results: The neonates mean age was 16.53±9.99 hours. There were 59 (59%) male and 41 (41%) female neonates. The mean gestational age of neonates at birth was 37.67±1.71 weeks. The mean birth weight of neonates was 2354.58±379.16 grams. The mean unconjugated bilirubin level was 7.55±1.45 mg/dl. There were 28 (28%) had ABO incompatibility.

Conclusion: Thus the frequency of ABO incompatibility was high in neonates with hyperbilirubinemia. So ABO incompatibility can be a risk factor for neonatal hyperbilirubinemia.