Influence of Celecoxib on Serum Urea Alongwith Favorable Effects of Lycopene on Albino Rats; An Investigational Study

Abstract

Objective: To evaluate the influence of celecoxib on serum urea along with enhancement by lycopene.

Study Design: Investigational Study

Place and Duration of Study: This study was conducted at the Animal House of BMSI, JPMC, Karachi from May, 4th May 2016 to 3rd June 2016.

Materials and Methods: Physically fit forty adult male Albino rats of 200-220gm and 90-120 days old were taken for this study and distributed into 4 groups, control group was chosen as Group1A, In Group 1B Celecoxib was given 50 mg/kg orally, In Group 1C Celecoxib was given 50 mg/kg with lycopene50 mg/kg orally and In Group 1D lycopene was given 50 mg/kg orally for 30 days. At accomplishment of study, animals were sacrifice and tissues were preserved for staining.

Results: In Group 1B serum urea was markedly raised, however serum level were amended in Group 1c which were given celecoxib with lycopene.

Conclusion: This study reveals that lycopene amended the serum deviations of Group 1B.