Effect on Mobility and Pain with Collagen Peptides in Knee Osteoarthritis in Pakistani Population

Abstract

Objective: To evaluate the effects on mobility and pain with the use of collagen active peptides in knee osteoarthritis patients in Pakistani Population.

Study Design: It is an open label randomized clinical trial study.

Place and Duration of Study: This study was conducted at the Tertiary Care Hospital, Karachi from Sep, 2020 to March, 2021 for a period of six months.

Materials and Methods: One hundred and ten patients were scheduled in the study suffering from knee osteoarthritis. They were divided into three groups; Group I Diacerein (n=37), Group II Collagen active peptides (n=37) and Group III NSAID’s (Diclofenac Potassium) (n=36).

Results: One hundred and two patients successfully completed the study with collagen active peptides improving the intensity of pain (VAS) visual analogue score at 6^th and 12^th weeks (p > 0.001) with highly significant results.

Conclusion: Collagen active peptides not only reduces pain and associated joint stiffness with OA but also enhances the functional mobility hence the quality of life improved with the use of collagen active peptides.