Clinical Characteristics and Histopathology of Corona Virus Disease 2020

Abstract

Objective: To investigate the clinical and histopathological characteristics of corona virus disease.

Study Design: Systamatic Review

Place and Duration of Study: This study was conducted at the Watim Medical and Dental College from Jan 2021 to June 2021.

Materials and Methods: All the articles published in 2020 at Google Scholar and PubMed were searched from to gather the information about the clinical and histopathological characteristics of corona virus disease. The articles published in English language only were included in this study. The terms like “clinical features of COVID-19”, “COVID-19”, “Histopathology of corona virus” and “Histology of COVID-19” were searched. I² and Egger’s test was used to analyze the data about the clinical characteristics of the patients.

Results: The most common comorbidities related to COVID-19 are hypertension in 16 % cases and cardiovascular and cerebrovascular diseases in 12 % of the cases. The histopathological changes were most evident in the lungs. According to the percentage the most common lungs findings were congestion and diffused alveolar damage with 97.8 %.  Corona virus disease also effects other organs and systems like CVS; myocardial hypertension, nervous system; hypoxic injury, digestive system; segmental dilatation and stenosis, liver; steatosis, kidney; acute tubular injury, immune system; coagulation abnormalities among many other.

Conclusion: TMultiple dysfunction caused by corona virus disease can occur due one of the following reasons: to direct viral attack, systemic inflammation, injury to the immune system or shock.