Significance of Platelet Count and D-Dimers Level in Carcinoma Prostate

Abstract

Objective: Analysis and recognition of coagulopathies in patients with carcinoma of prostate by carrying out platelet count and D-dimers level.

Study Design: Case-control study.

Place and Duration of Study: This study was conducted at ISRA Hospital, Hyderabad, Liaquat University of Medical & Health Sciences Hospital Hyderabad and NIMRA Jamshoro for a period of six months from from June 2011 to November 2011.

Materials and Methods: Cases were patients with prostatic carcinoma who were diagnosed on biopsy examination. Controls were normal healthy randomly selected age matched adult males from Hyderabad without prostatic carcinoma. A total of one hundred subjects were included in the study.

Results: In Group I (Cases), the mean platelet count was 197.52 x 103 and in Group II (Controls), the mean platelet count was 286.06 x 103. In Group I (Cases), the mean D-dimers level was 0.692 mg/L and in Group II (Controls), the mean D-dimers level was 0.146 mg/L.

Conclusion: Coagulopathies are frequently associated with prostate cancer and should be known to urologists and oncologists because they may compromise short-term prognosis and influence therapeutic strategies. Our results suggest that platelet count and D-dimer levels are altered in patients with prostate cancer.