Estrogen and Progesterone Receptor Status and Her-2/Neu Over expression in Breast Carcinoma with Relation to Age

Abstract

Introduction: Carcinoma of the breast is the common malignancy in Pakistani females. The study was conducted to assess estrogen receptor (ER), progesterone receptor (PR) and Her-2/neu over-expression in females with relation
to age.

Study Design: Institution based prospective study

Place and Duration of Study: This study was carried out at the Histopathology section in the Department of Pathology, LUMHS, Jamshoro from March 2010 to December 2011.

Materials and Methods: Fifty cases of breast carcinoma were selected to evaluate ER, PR and Her-2/neu over-expression by Immunohistochemistry (IHC).

Results: The predominant histologic morphology was Infiltrating duct cell carcinoma. Majority of the cases presented with grade-II (78.7%) with a mean age of 46.5 years. IHC performed on 50 cases revealed ER +ve in 34 (68%) cases with a mean age of 47.5 years and ER  -ve in 16 (32%) cases with a mean age of 44.5 years while PR +ve in 30 (60%) cases with mean age of 44.1 years and PR -ve in 20 (40%) cases with a mean age of 50.1 years. Her-2/neu over-expression was found in 15 (30%) cases with a mean age of 41.6 years and Her-2/neu -ve in 35 (70%) cases with a mean age of 48.6 years.

Conclusion: ER and PR expression was found at a significant level reflecting a good therapeutic and prognostic value but the frequency of Her-2/neu over-expression was high reflecting a bad prognosis.