Role of Latanoprost in the Treatment of Primary Open Angle Glaucoma

Abstract

Objective: The aim of this study was to observe the effect of Latanoprost in lowering intraocular pressure (IOP) in primary open angle glaucoma (POAG) patients.

Study Design: Prospective, open- label, Observational Study.

Place and Duration of Study: This study was conducted at the Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute, Jinnah Post-graduate Medical Centre, Karachi from February 2008 to July 2008.

Methods and Materials: Thirty patients of POAG were enrolled and were treated with Latanoprost 0.005% eye drops for 12 weeks. The parameter examined was IOP by using Goldmann applanation tonometer.

Results: The results have been expressed as mean ±SEM. The mean IOP of both eyes decreased significantly (from 27.16± 0.19 mmHg to 17.94± 0.23 mmHg; p<0.001). The average percentage reduction in IOP was -33.94% from week 0 to week 12.

Conclusion: Latanoprost 0.005% eye drops may become an important choice as a monotherapy for primary open angle glaucoma patients.