Significant High Lipid Profile in Pre-Hypertensive Subjects as Compare to Stage 1 and Stage 2 of Hypertensive Subjects

Abstract

Objective: To analyze the differences in lipid profile in various categories of hypertension in our local population.

Study Design: Cross Sectional Study

Place and Duration of study: This study was conducted at Amin Hayat Memorial Trust for diabetes and Hypertension, Lahore and Punjab Institute of Cardiology (PIC), Lahore from Dec. 2005 to May 2007.

Materials and Methods:   A total of 510 subjects of either sex were screened during a cross-sectional study.  Biochemical assessment includes the determination of TC (Total Cholesterol), LDL-C (Low Density Lipoprotein Cholesterol), HDL-C (High Density Lipoprotein Cholesterol), and TG (Triglycerides), which were measured by using commercially available kits using Hitachi 902 photometer. vLDL and LDL-C/HDL-C ratio was calculated by using formula.

Results: Abnormal lipid profile was observed in 59% of the study population. Around 75% of prehypertensive subjects had abnormal lipid profile as compare to stage 1 and stage 2 of hypertension. Beside prevalence significant high levels of TC, LDL-L, and LDL-C/HDL-C were also observed in prehypertensive group. Females had significantly high levels of TC, HDL-C and LDL-C/HDL-C compared to males.

Conclusion: A high prevalence of dyslipidemia was observed in all stages of hypertension; however, prehypertensive group had significant high levels of lipid profile and smoking and family history also predispose to high blood pressure.