First Trimester Termination of Pregnancy – Role of Sublingual Misoprostol

Abstract

Objective: The objective of this study was to evaluate the efficacy acceptability and dose of misoprostol sublingually in the management first trimester pregnancy failure.

Study Design: Observational Study

Place and Duration of Study:  This study was conducted in the Department of Obstetrics and Gynaecology at Peoples Medical College Hospital Nawabshah from 01.01.2010 to 31.12.2010.

Patients and Methods: A total 150 patients with the diagnosis of missed and incomplete miscarriage upto 13 weeks gestation. All eligible women who consented were counseled and given detail information protocol.

Results: A total of 150 patients with missed miscarriage 119 (79.33 %) and incomplete miscarriage 31 (20.66 %).The mean age group 28.34 years ,mean parity 4.79 and mean gestational age 8.61 weeks. Efficacy was 92 %, 127 (84.66 %) had complete miscarriage by the end of 7 days with 2 doses of misoprostol 600ug sublingually 3 hours apart. 23 (15.33 %) require 3^rd dose of misoprostol and 11 (7.33 %) underwent surgical evacuation. Patients satisfaction was 94 % (141 patients).

Conclusion: Misoprostol prove with benefit of efficacy, safety and acceptability in first trimester pregnancy failure. In low resources countries achieve infection haemorrhage and uterine damage can for two commonly reported on consequences of post surgical care. Misoprostol treatment can prove to be a rewarding step towards reducing morbidity and mortality.