Tuberculosis and Chronic Kidney Disease: Evaluating the Management Challenges and Treatment Strategies

Abstract

Objective: To find the relation between tuberculosis and chronic kidney disease and evaluating the management challenges and treatment strategies.

Study Design: Observational study

Place and Duration of Study: This study was conducted at the Gulab Devi Hospital, Lahore, from December 2022 to June 2023.

Methods: The inclusion criteria encompassed individuals aged 18 years and older who had been diagnosed with both TB and CKD, either on long-term dialysis or with documented CKD stages 3–5 (defined as estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73 m² for ≥3 months).

Results: Data was collected from 180 patients. Mean age was 57.1 ± 8.9 years. The distribution of CKD stages reveals that the majority of participants had CKD stage 3 or 4, with a smaller percentage in stage 5. Additionally, the table highlights that nearly half of the TB cases were pulmonary TB, while the remaining cases were extrapulmonary.

Conclusion: It is concluded that a potential positive impact of TB treatment on renal function in CKD patients, but further research is essential to confirm these observations and elucidate underlying mechanisms.