The Prevalence of Liver Diseases and Etiological Factors among the Patients of Jinnah Post Graduate Medical Centre (JPMC), Karachi

Abstract

Objective: To determine the frequency and etiological factors of nonneoplastic and neoplastic liver diseases

Study Design: Observational / analytic study.

Place and Duration of Study: This study was conducted at the Department of Pathology, BMSI, JPMC from 1st January 2012 to 31^st September 2014.

Materials and Methods: A total of 288 liver biopsycases of formalin fixed liver tissue biopsies were selected and analyzed for morphological features and grading received from January 2010-December 2012, at the department of Pathology, Basic Medical Sciences Institute, Jinnah Post Graduate Medical Centre.

Most common liver disease was CLD (88.54%). Most common age for CLD was between 3rd-5th decades of life with male predominance. HCV was the most common etiological factor. Out of total cases, 6.59% were hepatocellular and bile duct carcinomas. Most common age for liver cancers was 5th-7th decade of life with male predominance. The data feeding and analysis were on computer package SPSS (Statistical Packages of Social Sciences) version 20.0. In all statistical analysis only p-value <0.05 was considered significant.
Results: The most commonly encountered liver disease CLD was found as a major liver disease (71%) of the samples were suffering from CLD , while 25 % were suffering from HCC, Hepatitis C was the major cause of the liver diseases, (55.56%) of the liver patients were earlier suffering from the Hepatitis C.

Conclusion: In conclusion we observed that the most common liver disease in biopsy cases is chronic liver disease (chronic hepatitis), mostly occur between 21-50 years of age with male predominance and most frequent etiological factor is HCV.