Role of Histology in Lymphoma Classification

Abstract

Objective: To determine the usefulness of histopathology and immunohistochemistry in the precise identification of lymphomas in a retrospective cohort.

Study Design: Retrospective observational study
Place and Duration of Study: This study was conducted at the Department of Histopathology at King Fahad
Specialist Hospital in Dammam, Saudi Arabia from 15.03.2024 to 30.05.2024.

Methods: One hundred and fifty lymphoma cases 2020-2023 were analyzed using histomorphology and
immunohistochemistry per World Health Organization classification.

Results: There were 52 (35%) Hodgkin lymphoma and 98 (65%) non-Hodgkin lymphoma. The most common type
of non-Hodgkin lymphoma was diffuse large B-cell lymphoma (40%), and follicular lymphoma (18%). In 87%, immunohistochemistry was required to make a definitive classification.

Conclusion: The use of histology and immunohistochemistry cannot be replaced in the correct classification of
lymphoma and plays a crucial role in the choice of therapy and prognosis.