Comparison of Conventional Laparoscopic Cholecystectomy with Clips and Laparoscopic Cholecystectomy Using Ligasure (High Energy Vessel Sealing Devices) Without Clips in Terms of Hemostasis

Abstract

Objective: To determine and compare mean intraoperative blood loss and mean time for achieving hemostasis in patients undergoing laparoscopic cholecystectomy using clips versus LigaSure vessel sealing system.

Study Design: Randomized clinical trial study
Place and Duration of Study: This study was conducted at the Department of Surgery, Pakistan Ordnance Factories Hospital, Wah Cantt, over a period of six months from November 2025 till January 2026.

Methods: A total of 114 patients between 18–60 years of age undergoing elective laparoscopic cholecystectomy were included in this study using non-probability consecutive sampling and randomized into two equal groups. Group A underwent cystic artery ligation with titanium clips, while Group B underwent vessel sealing using LigaSure. Intraoperative blood loss and time for achieving hemostasis were recorded and analyzed using the
independent samples t-test.

Results: Patients in the LigaSure group demonstrated significantly lower mean intraoperative blood loss and shorter mean time to achieve hemostasis compared to the clip group (p ≤ 0.05).

Conclusion: LigaSure is a safe and effective alternative to titanium clips for cystic artery control in laparoscopic cholecystectomy and may provide superior hemostatic outcomes.