Correlation of Serum Irisin Level with Nerve Conduction Study in Diabetic Patients

Abstract

Objective: To assess irisin hormone in diabetic peripheral neuropathy and to assess the relation between irisin hormone and nerve conduction study.

Study Design: Meta-analysis of observational study
Place and Duration of Study: This study was conducted at the Marjan Teaching Hospital in Babil City in Endocrinology and Diabetes Center from 1st January 2025 to 31st March 2025.

Methods: Forty one diabetic patients divided into two groups, 22 patients with diabetic peripheral neuropathy and 19 patients without diabetic peripheral neuropathy. Patients with diabetic peripheral neuropathy are diagnosed based on history and clinical examination with assistance of Michigan Neuropathy Screening Instrument scoring system. Serum irisin, nerve conduction study of sural nerve (amplitude, velocity) and sural/radial amplitude ratio are doing for all patients.

Results: Irisin hormone level was significantly lower in patients with diabetic peripheral neuropathy (143.18 pg/ml) than patient without diabetic peripheral neuropathy (203.29 pg/ml), (p=0.0001) and the relation between irisin hormone and sural nerve conduction study and sural/radial amplitude ratio in both groups show no significant correlation.

Conclusion: The irisin hormone level is significantly decreased in DPN patients. There is no significant correlation between irisin and nerve conduction study of sural nerve and sural/radial amplitude ratio.