The Relationship Between Pentraxin-3, Procalcitonin and Glycemic Control in Diabetic Foot Infections

Abstract

Objective: To evaluate the relative importance of pentraxin-3, procalcitonin, C-reactive protein, glycated hemoglobin and body mass index as well as identify any correlations between these parameters.

Study Design: Case-control study
Place and Duration of Study: This study was conducted at the University of Babylon, College of Medicine, Iraq from 18th June to 24th September 2024.

Methods: Fifty participants with diabetic foot infection and fifty healthy individuals were among the one hundred people whose Pen-3, procalcitonin, C-reactive and glycated hemoglobin levels were estimated. The age range of patients and control subjects is 38 to 69 years. The sandwich-enzyme-linked immunosorbent assay kit and the colomeric technique were used to test the levels of pentraxin-3, procalcitonin and C-reactive protein in serum. The glycated hemoglobin kit was also used.

Results: There was a substantial rise in serum levels of pentraxin-3, procalcitonin and C-reactive protein as well as a significantly elevated glycated hemoglobin (p<0.001). However, glycated hemoglobin was a major relationship between pentraxin-3 and procalcitonin.

Conclusion: There is a substantial link between diabetic foot and variability, pentraxin-3 and procalcitonin among patients with diabetes.