Diagnosis and Effectiveness of Calcium Peroxide Nanoparticles Prepared from Capsicum Plant Extract against Colon Cancer

Abstract

Objective: To diagnose the function of natural biomolecules in the biological reduction of metal salts during nanoparticle synthesis.

Study Design: Experimental study
Place and Duration of Study: This study was conducted at the College of Education for Pure Sciences/Ibn Al- Haitham at the University of Baghdad from 1st January 2024 to 31st March 2025.

Methods: Capsicum plant extract was used and treated with a readily available inorganic salt (CaSO4 2H2O). It was used as a basic material to obtain particles.

Results: Calcium peroxide nanoparticles in the form of a yellowish-white powder were confirmed by using, UV, XRD, SEM, TEM, AFM, and EDX, confirmed that the compound is calcium peroxide nanoparticles with an average nano size of 31.288 nm. The effectiveness of these particles against colon cancer (HT-29) was clearly and reliably demonstrated by diagnostic tests and examinations of infected laboratory cells cultured.

Conclusion: The use of calcium peroxide nanoparticles represents a novel approach to cancer treatment, focusing on developing imaging and therapeutic methodologies.