Management and Clinical Assessment of Dermatitis in the presence of Barrier Dysfunction and Scaling: A Comparative Analysis of the Efficacy of SVR Topialyse Baume Protect+ in Improving the Skin Barrier Function

Abstract

Objective: To evaluate the effectiveness of treatment in the presence of barrier dysfunction and scaling.

Study Design: A prospective randomized controlled trial study
Place and Duration of Study: This study was conducted took place in two dermatology centers in Baghdad, Iraq: Al-Zahraa Teaching Hospital and Tamara Skin and Laser Clinic from 1st October 2024 to 31st December 2024.

Methods: comparing 100 cases with moderate dermatitis to either SVR Topialyse Baume Protect+ (enriched with ceramide) or a standard moisturizer (10per cent glycerin + mineral oil) after four weeks. The results were SCORAD index, TEWL, patient-reported itch (VAS), and digital image analysis.

Results: Experimental group registered a 40 percent drop in SCORAD (60.0 36.0), 40 percent reduce in TEWL (25.0 15.0 g/m 2 /h) and 65 percent enhancement in itch (8.5-3.0 on VAS) which was significantly more than controls ( p < 0.001). Scaling, erythema and fissures showed significant improvement as evidenced by digital imaging.

Conclusion: SVR Topialyse Baume Protect+ is more effective based on active repair of the lipid barrier and provides a pathophysiology-based method of treating dermatitis.