Association of Serum Vitamin D Levels with Disease Severity among Patients with Chronic Rhinosinusitis in Mirpur, Azad Jammu and Kashmir

Abstract

Objective: The objective of the present study was to investigate the association between serum vitamin D levels and the severity of disease among patients with chronic rhinosinusitis(CRS)in Mirpur, Azad Jammu and Kashmir (AJK).

Study Design: Cross-sectional study
Place and Duration of Study: This study was conducted at the Community Medicine and ENT Department of MBBS Medical College, Mirpur AJK from 20th March 2024 to 19th February, 2025.

Methods: The present study was ethically approved by the Local Ethics Committee of MBBS Medical College, Mirpur, AJK, and written informed consent was duly obtained from all participants prior to inclusion and this cross-sectional study was Conducted at The Department Of Community Medicine and ENT department of MBBS Medical College, Mirpur AJK Serum 25-hydroxyvitamin D [25(OH)D] concentrations were quantitatively measured using a Euroimmun commercial kit, which was specifically designed based on the enzyme-linked immunosorbent assay (ELISA) principle. Sino nasal symptom severity and its impact on quality of life were
assessed comprehensively using the Sino nasal Outcome Test-22 (SNOT-22) questionnaire. All participants were adequately instructed regarding its completion to maximize accuracy

Result: The mean serum vitamin D concentration was measured at 24.7 ± 16.8 ng/mL, indicating an overall tendency toward vitamin D insufficiency. When analyzed separately, a mean level of 23.2 ± 11.6 ng/mL was
observed among males, while a mean level of 23.8 ± 19.2 ng/mL was noted among females. A significant negative correlation (r = –0.22, P = 0.034) was revealed by the Pearson correlation coefficient between serum vitamin D
levels and SNOT-22 scores. This inverse relationship indicated that lower serum vitamin D concentrations were associated with higher SNOT-22 scores, thereby reflecting more severe symptoms and a greater negative impact on patients’ quality of life.

Conclusion: These findings strongly indicated that the severity of chronic rhinosinusitis was directly correlated with deficiency of vitamin D. Hence, it may be said that the maintenance of adequate levels of vitamin D could be
potentially associated with better symptom control & improved life quality among patients distress with rhinosinusitis.