Recognize the Relationship Between Autoimmune Disease as Rheumatism with Multi vitamin Deficiency

Abstract

Objective: To identify associated risk factors in RA. The highest reported prevalence for RA was in the 42-52 years age group, with lower prevalence in over 80-year-old, for whom diagnosis may be more difficult.

Study Design: Cross-sectional case-control study

Place and Duration of Study: This study was conducted at the Thi-Qar Governorate in south of Iraq from 1st February 2025 to 30th June 2025.

Methods: The link between vitamin D deficiency and rheumatoid arthritis and its possible consequences on disease activity and coexisting diseases were assessed. Fifty patients who had been clinically diagnosed with rheumatoid arthritis according to the 2010 ACR/EULAR classification criteria were enrolled from rheumatology clinics and hospitals in the area. A group of healthy subjects, age- and sex-matched and without any autoimmune and chronic inflammatory diseases was also studied for comparisons.
Results: Males had a higher prevalence of Anaplasia compared to females, which might be associated with genetic and immune-related differences between males and females. Diabetic patients were more frequently infected (42%) than hypertensive patients (36%), indicating different effects of comorbidities on the progression of infection. In terms of hematological findings, mild anemia due to chronic inflammation was suspected in all cases, with significant vitamin D3 deficiency identified in more than 80% of cases.

Conclusion: Vitamin D has an immunity-regulating role and could be useful in rheumatoid arthritis treatment. A global integrated strategy taking into account comorbid conditions, nutritional deficiencies and demographics in relation to vitamin D supplementation could potentially result better outcomes. In the future, more studies are required to improve the diagnosis and treatment of rheumatoid arthritis.