Investigated the Link between Some Cytokines and Gene Expression of Gastritis in Type 2 Diabetic Patients in Iraq

Abstract

Objective: To investigate immunological and molecular features of gastritis in individuals with diabetes mellitus.
Study Design: Comparative study
Place and Duration of Study: This study was conducted at the Gastroenterology & Hepatology Teaching Hospital, Medical City, Baqubah Teaching Hospital, and Al-Kazemi Teaching Hospital, Department of Gastroenterology, from 1st January 2024 to 30th April 2024.
Methods: A total of 138 participants including 67 H. pylori gastritis with type 2 diabetic (GHp+ve DM) group, 21 with gastritis without diabetes mellitus (G group), and 50 control group.
Results: The GHp+ve, diabetes mellitus had reduced levels. Regarding IL-10 in comparison to G and control, IL-18 levels increased in GHp+ve. In addition, discovered GHp+ve diabetes mellitus had lower levels of IL-10 than G (p<0.05). Moreover, found IL-18 more highly expressed in GHp+ve DM than in gastritis (p<0.05).
Conclusion: The gastritis by H. pylori infection to type 2 diabetes and shows IL-10 levels reduced in GHp +ve diabetes mellitus contrast with gastritis group and healthy controls and inversely correlated with high-sensitivity C- reactive protein, IL-18 levels raised in GHp +ve.