Assessment of Beta-Catenin Levels and Related Biomarkers in Patients with Chronic Kidney Disease

Abstract

Objective: To contrast the alterations in serum concentrations of insulin-like growth factor-1 (IGF-1), β-catenin, calcium, vitamin D, parathyroid hormone (PTH), and phosphorus in renal failure patients with those in normal controls, and to contrast between-group differences to further define the biochemical derangements in renal failure. 
Study Design: Comparative study 
Place and Duration of Study: This study was conducted at the Iraqi hospitals and kidney disease centers from 7th August 2022 to 1st April 2023. 
Methods: The study included 400 samples, control 100 and patients 300. Three groups were formed; each group was made up of 100 patients. These groups varied in age. Patients with cancer, and pregnant women were not included. 
Results: Insulin-like growth factor-1, β-catenin, calcium and vitamin D, levels and increase in parameters parathyroid hormone and phosphorus varied significantly amongst the groups, according to the data. The first group, followed by the second and third groups, showed the lowest levels, while all three groups showed lower levels than the control group. 
Conclusion: The reduction in the levels of IGF-1, β-catenin, calcium and vitamin D and increase in parameters parathyroid hormone and phosphorus.