Ferritin Relationship with Clinical Changes, Nutrient Elements, Vitamins D and C and Liver, Kidney Functions in Beta-Thalassemia Major Patients

Abstract

Objective: The current study was carried out to study ferritin levels and their effect on nutrient and Vitamins C&D levels in patient with beta thalassemia major. 

Study Design: Case series study 

Place and Duration of Study: This study was conducted at the Department of Biochemistry, Thalassemia Center for Genetic Blood Diseases in Thi Qar University, southern Iraq from November 2023 to April 2024. 

Methods: Current study studied 48 cases of beta thalassemia major and 44 healthy as controls, aged range (8-22) years. Biochemical and hemotograte ferritin, calcium, potassium, iron, sodium, D and C vitamins. Enzymes were measured: alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, urea, creatinine and total Bilirubin levels. 

Results: The study found highly statistically significant in ferritin  (1624.81 μg/L) and   a significant decrease in   hemoglobin (Hb) levels (7.205 g/dL) vitamins D and C recorded   17.319 μg/L, 1.202mg/dl respectively,  also   a significant increase in AST (39.38 IU/L) ,  ALT (58.71 IU/L )and TSB  (2.52 mg/dL), and a decrease  in ALP( 73.90IU/L) ,urea (27.01mg/dL) and Creatinine (0.80mg/dL), also calcium ( 3.03 mg/dL), (P > 0.05) and potassium (3.08mmol/L)  and a significant increase in sodium  (139.14 mmol/L)  and iron (164.47μg/dL) in  patients compared to healthy group. 

Conclusion: The present study showed differences in ferritin, calcium, potassium, sodium, ions, and vitamins D and C content in the serum of beta thalassemia patients compared with the control group.