Efficacy and Safety of Combining Micro-Needling with Platelet-Rich Plasma (PRP) for the Treatment of Post-Acne Scars: A Clinical Outcome Analysis

Abstract

Objective: To evaluate the efficacy and safety of microneedling combined with PRP compared to microneedling with saline placebo for the treatment of post-acne scars. 

Study Design: A prospective study Place and Duration of Study: This study was conducted at the Superior University Lahore during July 2024 to December 2024. 

Methods: A prospective study was with 65 participants aged 18–45 years. Group A (n=33) received microneedling with PRP, and Group B (n=32) received microneedling with saline. Scar severity, patient satisfaction, and skin texture were assessed using Goodman and Baron’s grading system, satisfaction scores, and imaging. Adverse effects were recorded. Statistical analysis included paired t-tests and chi square tests, with p<0.05 considered significant. 

Results: Group A demonstrated a significant improvement in scar severity (43%) compared to Group B (19%), with a p-value of <0.01. Patient satisfaction was higher in Group A (80% “very satisfied”) versus Group B (53%, p<0.01). Both groups experienced mild, transient adverse effects such as erythema and edema, with no severe complications reported. 

Conclusion: Microneedling combined with PRP is a safe and effective treatment for post-acne scars, offering superior improvements in scar severity and patient satisfaction compared to microneedling alone. Its favorable safety profile and clinical efficacy make it a promising option for scar management.