Frequency of Thyroid Dysfunction in Patients with Gestational Diabetes
DOI:
https://doi.org/10.60110/medforum.360301Keywords:
Gestational diabetes, Pregnancy, Thyroid dysfunction, Third trimester, maternal outcomeAbstract
Objective: To determine the frequency of thyroid dysfunction in patients with gestational diabetes.
Study Design: Cross sectional study Place and Duration of Study: This study was conducted at the Department of Obstetrics and Gynaecology, Dow International Medical College from June 2023-December 2023.
Methods: Informed consent was taken. All pregnant women who visited to OPD during 24-28 weeks gestation with gestational diabetes confirmed from 75gm oral glucose tolerance test(OGTT), fasting ≥ 5.1 mmol/l (92 mg/dl); 1-h ≥ 10.0 mmol/l (180 mg/dl); or 2-h ≥ 8.5 mmol/l (153 mg/dl) were subjected for the assessment of serum TSH level for thyroid dysfunction. If patient with serum TSH levels < 0.3 was considered as hyperthyroidism. Patients with serum TSH levels > 4.0 was considered as hypothyroidism. In both cases patient were categorized for thyroid dysfunction. Patients demographic information, such as age, BMI and socioeconomic status were recorded in a self-designed proforma. Women with preexisting diabetes and thyroid dysfunction were excluded.
Results: This study was conducted on 213 pregnant patients presenting with gestational diabetes. The mean age of the patients recorded was 29.60±5.93 years. The mean height of the patients was 1.65±0.03 meter. The mean weight of the patients was 72.60±441 kg and the mean BMI recorded was 26.70±20.01 kg/m2.
In our study there were 113 (53.1%) patients in the age group of 20 to 30 years and there were 100 (46.9%) patients in the age group of 31 to 40 years. The frequency of thyroid dysfunction in patients with gestational diabetes in our study was 30 (14.1%)
Conclusion: The prevalence of thyroid dysfunction in gestational diabetes was 14.08%, therefore screening should be offered to high risk pregnant women.
References
McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nat Rev Dis Primers 2019;5(1):1-9. DOI: https://doi.org/10.1038/s41572-019-0098-8
Spaight C, Gross J, Horsch A, Puder JJ. Gestational Diabetes Mellitus. Endocr Dev 2016; 31:163-78. DOI: https://doi.org/10.1159/000439413
Cho MK. Thyroid dysfunction and subfertility. Clin Exp Reprod Med 2015;42(4):131. DOI: https://doi.org/10.5653/cerm.2015.42.4.131
Oliveira KJ, Chiamolera MI, Giannocco G, Pazos- Moura CC, Ortiga-Carvalho TM. Thyroid function disruptors: from nature to chemicals. J Mol Endocrinol 2019;62(1):1-9. DOI: https://doi.org/10.1530/JME-18-0081
Kravets I. Hyperthyroidism: diagnosis and treatment. Am Fam Phys 2016;93(5):363-70.
Chiovato L, Magri F, Carle A. Hypothyroidism in context: where we’ve been and where we’re going. Adv Ther 2019;36(2):47-58. DOI: https://doi.org/10.1007/s12325-019-01080-8
Arif R, Mazhar T, Bukhari N. Frequency of thyroid dysfunction in pregnant women with diabetes. JMed Sci 2019;27(2):98-102.
Maleki N, Tavosi Z. Evaluation of thyroid dysfunction and autoimmunity in gestational diabetes mellitus and its relationship with postpartum thyroiditis. Diabet Med 2015; 32(2):206-12. DOI: https://doi.org/10.1111/dme.12580
Shi X, Han C, Li C, Mao J, Wang W, Xie X, et al. Optimal and safe upper limits of iodine intake for early pregnancy in iodine-sufficient regions: a cross-sectional study of 7190 pregnant women in China. J Clin Endocrinol Metab 2015;100(4): 1630-8. DOI: https://doi.org/10.1210/jc.2014-3704
Muir CA, Munsif A, Blaker K, Feng Y, D’Souza M, Tewari S. Antenatal thyroid function does not increase risk of gestational diabetes mellitus in a multi-ethnic pregnancy cohort. Int J Thyroidol 2020;13(1):13-8. DOI: https://doi.org/10.11106/ijt.2020.13.1.13
Arif R, Mazhar T, Bukhari N. Frequency of thyroid dysfunction in pregnant women with diabetes. J Med Sci 2019;27(2):98-102.
Al Shanqeeti SA, Alkhudairy YN, Alabdulwahed AA, Ahmed AE, Al-Adham MS, Mahmood NM. Prevalence of subclinical hypothyroidism in pregnancy in Saudi Arabia. Saudi Med J 2018;39(3):254. DOI: https://doi.org/10.15537/smj.2018.3.21621
Gallas PR, Stolk RP, Bakker K, Endert E, Wiersinga WM. Thyroid dysfunction during pregnancy and in the first postpartum year in women with diabetes mellitus type 1. Eur J Endocrinol 2002;147(4):443-51. DOI: https://doi.org/10.1530/eje.0.1470443
Fatima SS, Rehman R, Butt Z, Asif Tauni M, Fatima Munim T, Chaudhry B, et al. Screening of subclinical hypothyroidism during gestational diabetes in Pakistani population. J Maternal-Fetal Neon Med 2016;29(13):2166-70. DOI: https://doi.org/10.3109/14767058.2015.1077513
Endocrinology id. public health endocrinology. Ind J Endocrinol Metabol 2020;24(5):453.
Haddow JE, Craig WY, Neveux LM, Palomaki GE, Lambert-Messerlian G, Malone FD, D’Alton ME, First and Second Trimester Risk of
Aneuploidy (FaSTER) Research Consortium. Free thyroxine during early pregnancy and risk for gestational diabetes. PLoS One 2016;11(2): DOI: https://doi.org/10.1371/journal.pone.0149065
e0149065.
Ouyang F, Shen F, Jiang F, Hu H, Pan M. Risk factors in women with gestational diabetes mellitus. Zhonghua yu fang yi xue za zhi [Chinese
J Prevent Med] 2002;36(6):378-81. DOI: https://doi.org/10.1023/A:1021066523424
Bian X, Gao P, Xiong X, Xu H, Qian M, Liu S. Risk factors for development of diabetes mellitus in women with a history of gestational diabetes
mellitus. Chin Med J 2000;113(8):759-62. DOI: https://doi.org/10.1242/jcs.113.5.759




























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