Frequency of H. Pylori Infection among Dyspeptic Patients and Correlation with Histopathological Evaluation

Abstract

Objective: To determine the frequency of H. Pylori infection among dyspeptic patients through histopathological 
evaluation. 
Study Design: Descriptive cross-sectional Study 
Place and Duration of Study: This study was conducted at the Gastroenterology Department of Ziauddin Medical 
University Hospital in Karachi from November 2, 2022, to May 1, 2023. 
Materials and Methods: Patients between the ages of 18 and 60 who had dyspepsia and requested an endoscopic 
biopsy were enlisted. Samples were gathered and transported for histopathological analysis in a formalin bottle. 
Hematoxylin-eosin was used to stain the section in the histopathology lab. Using SPSS, data analysis was carried 
out. Data presentation using descriptive statistics. The percentages used to express categorical variables. For a 
continuous variable, the mean and standard deviation were calculated. H. Pylori infection frequency was given as a 
percentage. 
Results: There were 101 females and 95 males. The median age of the group was 39.54 ± 12.91 years. 39 patients 
had H. Pylori, which was diagnosed. Among the 196 individuals, 79 had mild gastritis while the remaining 117 had 
moderate gastritis. Thirty (30.6%) male patients and nine (8.9%) female patients had H. Pylori. H. Pylori is highly 
correlated with gender, although there is no correlation between gender and mild or severe chronic gastritis. H. 
Pylori was discovered in 13 (21.3%), 9 (22.5%), 6 (13.0%), and 11 (22.4%) patients, respectively, in the age ranges 
of 18–30, 31–40, 41–50, and 51–60. With regard to age groups and H. Pylori, no meaningful correlation was 
discovered. The mild chronic gastritis was discovered in 27 (44.3%), 17 (42.5%), 14 (30.4%), and 21 (42.9%) 
patients, respectively, in the age groups of 18–30, 31–40, 41–50, and 51–60. 34 patients (55.7%), 23 patients 
(57.5%), 32 patients (69.6%), and 28 patients (75.1%) in the age categories of 18 to 30, 31 to 40, 41 to 50, and 51 to 
60 years, respectively, had mild chronic gastritis. 
Conclusion: According to the study's findings, H. Pylori is very common among dyspeptic patients who were 
diagnosed using biopsy-based techniques. A sizable section of the Pakistani population is infected with H. Pylori, 
and the H. Pylori status of a person presenting with disorders that have a strong association with this organism 
should be taken into consideration.